We are a chemical biology lab that develops new chemical tools and technologies to study and manipulate biological systems. We use interdisciplinary approaches integrating organic synthesis, fluorescence imaging, mass spectrometry, and omics analyses, together with molecular and cell biology and mouse models. Our goal is to identify targetable sites on disease-related proteins and to develop drug candidates for effective therapies.
News and updates
Sep 06, 2025
•Amy, Jason, Sandy and Hillary’s work on a RhoA covalent inhibitor has been published online in Cell Chemical Biology (https://doi.org/10.1016/j.chembiol.2025.08.004). An amazing collaboration with Prof Jingying Zhou, Prof Stephanie Ma, Prof SY Leung and Prof Helen Yan!
July 30, 2025
•Amy’s work on a AGPAT4 covalent inhibitor has been published online in Science Translational Medicine (https://doi.org/10.1126/scitranslmed.adn9472). Wonderful collaboration with Prof Stephanie Ma, Johnson Ng and other SMA’s lab members!
Jun 15, 2025
•Amy’s work on a detailed protocol in using NAIA for chemoproteomics has been published online as a book chapter in Methods in Molecular Biology (https://doi.org/10.1007/978-1-0716-4502-4_18).
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