Publication
Representative publications
Chemical biology, chemoproteomics, therapeutic covalent ligands
1. Koo, T.-Y.,† Lai, H.,† Nomura, D. K., & Chung, C. Y.-S.* (2023). N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nature Communications, 14(1), 3564. († These authors contributed equally)
2. Chung, C. Y.-S.,† Shin, H. R.,† Berdan, C. A., Ford, B., Ward, C. C., Olzmann, J. A., Zoncu, R.,* & Nomura, D. K.* (2019). Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nature Chemical Biology, 15(8), 776–785. († These authors contributed equally; * co-corresponding authors)
** Featured in News and Views in Nature Chemical Biology, 2019, 15(8), 760.
Redox biology and molecular probes
1. Lai, H., & Chung, C. Y.-S.* (2024). Superoxide-responsive quinone methide precursors (QMP-SOs) to study superoxide biology by proximity labeling and chemoproteomics. RSC Chemical Biology. https://doi.org/10.1039/D4CB00111G
2. Lee, S.,† Chung, C. Y.-S.,† Liu, P., Craciun, L., Nishikawa, Y., Bruemmer, K. J., Hamachi, I., Saijo, K., Miller, E. W., & Chang, C. J. (2020). Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper. Journal of the American Chemical Society, 142(35), 14993–15003. († These authors contributed equally)
3. Chung, C. Y.-S., Posimo, J. M., Lee, S., Tsang, T., Davis, J. M., Brady, D. C., & Chang, C. J. (2019). Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism. Proceedings of the National Academy of Sciences, 116(37), 18285.
4. Chung, C. Y. S., Timblin, G. A., Saijo, K., & Chang, C. J. (2018). Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining. Journal of the American Chemical Society, 140(19), 6109–6121.
Cancers
1. Husain, A., Chiu, Y.-T., Sze, K. M.-F., Ho, D. W.-H., Tsui, Y.-M., Suarez, E. M. S., Zhang, V. X., Chan, L.-K., Lee, E., Lee, J. M.-F., Cheung, T.-T., Wong, C. C.-L., Chung, C. Y.-S., & Ng, I. O.-L. (2022). Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma. Journal of Hepatology, 77(2), 383–396.
2. Chan, K. K.-S., Au, K.-Y., Suen, L.-H., Leung, B., Wong, C.-Y., Leow, W.-Q., Lim, T. K.-H., Ng, I. O.-L., Chung, C. Y.-S., & Lo, R. C.-L. (2023). Sortilin-Driven Cancer Secretome Enhances Tumorigenic Properties of Hepatocellular Carcinoma via de Novo Lipogenesis. American Journal of Pathology, 193(12), 2156–2171.
3. Huang, H., Tsui, Y.-M., Ho, D. W.-H., Chung, C. Y.-S., Sze, K. M.-F., Lee, E., Cheung, G. C.-H., Zhang, V. X., Wang, X., Lyu, X., & Ng, I. O.-L. (2024). LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress. Hepatology, 79(2), 323-340.
4. Bao, M. H.-R., Yang, C., Tse, A. P.-W., Wei, L., Lee, D., Zhang, M. S., Goh, C. C., Chiu, D. K.-C., Yuen, V. W.-H., Law, C.-T., Chin, W.-C., Chui, N. N.-Q., Wong, B. P.-Y., Chan, C. Y.-K., Ng, I. O.-L., Chung, C. Y.-S., Wong, C.-M., & Wong, C. C.-L. (2021). Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer. Cell Reports, 34(4).
5. Mao, X., Tey, S. K., Yeung, C. L. S., Kwong, E. M. L., Fung, Y. M. E., Chung, C. Y. S., Mak, L.-Y., Wong, D. K. H., Yuen, M.-F., Ho, J. C. M., Pang, H., Wong, M. P., Leung, C. O.-N., Lee, T. K. W., Ma, V., Cho, W. C.-S., Cao, P., Xu, X., Gao, Y., & Yam, J. W. P. (2020). Nidogen 1-Enriched Extracellular Vesicles Facilitate Extrahepatic Metastasis of Liver Cancer by Activating Pulmonary Fibroblasts to Secrete Tumor Necrosis Factor Receptor 1. Advanced Science, 7(21), 2002157.
Full Publication List
36. Lai, H., & Chung, C. Y.-S.* (2024). Superoxide-responsive quinone methide precursors (QMP-SOs) to study superoxide biology by proximity labeling and chemoproteomics. RSC Chemical Biology, 5(9), 924–937. https://doi.org/10.1039/D4CB00111G
**In the themed collection: 2024 RSC Chemical Biology Emerging Investigators**
35. Lam, Y.-Y., Lee, N.-S., Lee, S.-F., & Chung, C. Y.-S.* (2023). Organometallic d6, d8 and d10 metal complexes for biosensing and imaging, cancer therapy and theranosis. Journal of Organometallic Chemistry, 122982. https://doi.org/10.1016/j.jorganchem.2023.122982 35. Lam, Y.-Y., Lee, N.-S., Lee, S.-F., & Chung, C. Y.-S.* (2023). Organometallic d6, d8 and d10 metal complexes for biosensing and imaging, cancer therapy and theranosis. Journal of Organometallic Chemistry, 122982. https://doi.org/10.1016/j.jorganchem.2023.122982
34. Chan, K. K.-S., Au, K.-Y., Suen, L.-H., Leung, B., Wong, C.-Y., Leow, W.-Q., Lim, T. K.-H., Ng, I. O.-L., Chung, C. Y.-S., & Lo, R. C.-L. (2023). Sortilin-Driven Cancer Secretome Enhances Tumorigenic Properties of Hepatocellular Carcinoma via de Novo Lipogenesis. American Journal of Pathology, 193(12), 2156–2171. https://doi.org/10.1016/j.ajpath.2023.08.005
33. Huang, H., Tsui, Y. M., Ho, D. W., Chung, C. Y.-S., Sze, K. M., Lee, E., Cheung, G. C., Zhang, V. X., Wang, X., Lyu, X., & Ng, I. O. (2024). LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress. Hepatology (Baltimore, Md.), 79(2), 323–340. https://doi.org/10.1097/HEP.0000000000000523
32. Koo, T.-Y., Lai, H., Nomura, D. K., & Chung, C. Y.-S.* (2023). N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nature Communications, 14(1), 3564. https://doi.org/10.1038/s41467-023-39268-w
31. Hoshi, K., Messina, M. S., Ohata, J., Chung, C. Y.-S., & Chang, C. J. (2022). A puromycin-dependent activity-based sensing probe for histochemical staining of hydrogen peroxide in cells and animal tissues. Nature Protocols. https://doi.org/10.1038/s41596-022-00694-7
30. Tey, S. K., Wong, S. W. K., Yeung, C. L. S., Li, J. Y. K., Mao, X., Chung, C. Y.-S., & Yam, J. W. P. (2022). Liver cancer cells with nuclear MET overexpression release translation regulatory protein-enriched extracellular vesicles exhibit metastasis promoting activity. Journal of Extracellular Biology, 1(5), e39. https://doi.org/10.1002/jex2.39
29. Husain, A., Chiu, Y.-T., Sze, K. M.-F., Ho, D. W.-H., Tsui, Y.-M., Suarez, E. M. S., Zhang, V. X., Chan, L.-K., Lee, E., Lee, J. M.-F., Cheung, T.-T., Wong, C. C.-L., Chung, C. Y.-S., & Ng, I. O.-L. (2022). Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2022.02.018
28. Bao, M. H.-R., Yang, C., Tse, A. P.-W., Wei, L., Lee, D., Zhang, M. S., Goh, C. C., Chiu, D. K.-C., Yuen, V. W.-H., Law, C.-T., Chin, W.-C., Chui, N. N.-Q., Wong, B. P.-Y., Chan, C. Y.-K., Ng, I. O.-L., Chung, C. Y.-S., Wong, C.-M., & Wong, C. C.-L. (2021). Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108676
27. Mao, X., Tey, S. K., Yeung, C. L. S., Kwong, E. M. L., Fung, Y. M. E., Chung, C. Y. S., Mak, L.-Y., Wong, D. K. H., Yuen, M.-F., Ho, J. C. M., Pang, H., Wong, M. P., Leung, C. O.-N., Lee, T. K. W., Ma, V., Cho, W. C.-S., Cao, P., Xu, X., Gao, Y., & Yam, J. W. P. (2020). Nidogen 1-Enriched Extracellular Vesicles Facilitate Extrahepatic Metastasis of Liver Cancer by Activating Pulmonary Fibroblasts to Secrete Tumor Necrosis Factor Receptor 1. Advanced Science, 7(21), 2002157. https://doi.org/10.1002/advs.202002157
26. Lee, S.,† Chung, C. Y.-S.,† Liu, P., Craciun, L., Nishikawa, Y., Bruemmer, K. J., Hamachi, I., Saijo, K., Miller, E. W., & Chang, C. J. (2020). Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper. Journal of the American Chemical Society, 142(35), 14993–15003. https://doi.org/10.1021/jacs.0c05727 (†These authors contributed equally)
Publications before starting independent research
25. Tang, F. K., Yu, Z. H., Wong, T. H.-F., Chung, C. Y.-S., Hirao, H., & Au-Yeung, H. Y. (2020). Fluorescein-Containing Superoxide Probes with a Modular Copper-Based Trigger. ChemPlusChem, 85(4), 653–658. https://doi.org/10.1002/cplu.202000059
24. Chung, C. Y.-S.,† Posimo, J. M.,† Lee, S.,† Tsang, T.,† Davis, J. M., Brady, D. C.,# & Chang, C. J.# (2019). Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism. Proceedings of the National Academy of Sciences, 116(37), 18285. https://doi.org/10.1073/pnas.1904610116 (†These authors contributed equally; #co-corresponding authorship)
23. Chung, C. Y.-S.,† Shin, H. R.,† Berdan, C. A., Ford, B., Ward, C. C., Olzmann, J. A., Zoncu, R.,# & Nomura, D. K.# (2019). Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nature Chemical Biology, 15(8), 776–785. https://doi.org/10.1038/s41589-019-0308-4 (†These authors contributed equally; #co-corresponding authorship)
**Featured in News and Views in Nat. Chem. Biol., 2019, 15, 760.
22. Ward, C. C., Kleinman, J. I., Brittain, S. M., Lee, P. S., Chung, C. Y.-S., Kim, K., Petri, Y., Thomas, J. R., Tallarico, J. A., McKenna, J. M., Schirle, M., & Nomura, D. K. (2019). Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chemical Biology, 14(11), 2430–2440. https://doi.org/10.1021/acschembio.8b01083
21. Chung, C.Y.-S., Timblin, G. A., Saijo, K., & Chang, C. J. (2018). Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining. Journal of the American Chemical Society, 140(19), 6109–6121. https://doi.org/10.1021/jacs.8b02279
20. Yu, Z. H.,† Chung, C. Y.-S.,† Tang, F. K.,† Brewer, T. F., & Au-Yeung, H. Y. (2017). A modular trigger for the development of selective superoxide probes. Chemical Communications, 53(72), 10042–10045. https://doi.org/10.1039/C7CC05405J († These authors contributed equally)
19. Siu, S. K.-L., Chung, C. Y.-S., & Yam, V. W.-W. (2017). Amphiphilic oligo(ethylene glycol)- and poly(ethyleneoxide)-block-poly(propylene oxide)-block-poly-(ethylene oxide)-containing cyclometalated alkynylgold(III) complexes: From basic photophysics to self-assembly and stimuli-responsive properties. Journal of Organometallic Chemistry, 845, 177–188. https://doi.org/10.1016/j.jorganchem.2017.04.035
18. Cheng, H.-K., Chung, C. Y.-S., Zhang, K., & Yam, V. W.-W. (2017). Simple and Versatile Preparation of Luminescent Amphiphilic Platinum(II)-containing Polystyrene Complexes With Transformable Nanostructures Assisted by Pt⋅⋅⋅Pt and π–π Interactions. Chemistry – An Asian Journal, 12(13), 1509–1516. https://doi.org/10.1002/asia.201700123
17. Chung, C. Y.-S., Fung, S.-K., Tong, K.-C., Wan, P.-K., Lok, C.-N., Huang, Y., Chen, T., & Che, C.-M. (2017). A multi-functional PEGylated gold(iii) compound: Potent anti-cancer properties and self-assembly into nanostructures for drug co-delivery. Chemical Science, 8(3), 1942–1953. https://doi.org/10.1039/C6SC03210A
To be updated.