Representative publications

1. Chemical biology, chemoproteomics, activity-based protein profiling (ABPP), covalent ligands

Lai, H, Koo, T.-Y., Nomura D. K. & Chung, C. Y.-S.*, N-Acryloylindole-alkyne (NAIA) enables profiling new ligandable hotspots in chemoproteomics experiments and imaging thiol oxidation. ChemRxiv.


Chung, C. Y.-S.,† Shin, H. R.,† Berdan, C. A., Ford, B., Ward, C. C., Olzmann, J. A., Zoncu, R.,# & Nomura, D. K.# (2019). Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nature Chemical Biology, 15(8), 776–785. (†These authors contributed equally; #co-corresponding authorship)

**Featured in News and Views in Nat. Chem. Biol., 2019, 15, 760)

2. Redox biology, molecular probes, fluorescence imaging

Chung, C.Y.-S., Timblin, G. A., Saijo, K., & Chang, C. J. (2018). Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining. Journal of the American Chemical Society, 140(19), 6109–6121.

Chung, C. Y.-S.,† Posimo, J. M.,† Lee, S.,† Tsang, T.,† Davis, J. M., Brady, D. C.,# & Chang, C. J.# (2019). Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism. Proceedings of the National Academy of Sciences, 116(37), 18285. (†These authors contributed equally; #co-corresponding authorship)

Lee, S.,† Chung, C. Y.-S.,† Liu, P., Craciun, L., Nishikawa, Y., Bruemmer, K. J., Hamachi, I., Saijo, K., Miller, E. W., & Chang, C. J. (2020). Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper. Journal of the American Chemical Society, 142(35), 14993–15003. (†These authors contributed equally)

3. Nanomedicines, self-assembly, cancer therapy

Chung, C. Y.-S., Fung, S.-K., Tong, K.-C., Wan, P.-K., Lok, C.-N., Huang, Y., Chen, T., & Che, C.-M. (2017). A multi-functional PEGylated gold(iii) compound: Potent anti-cancer properties and self-assembly into nanostructures for drug co-delivery. Chemical Science, 8(3), 1942–1953.